CLIC1 and familial pancreatic carcinoma: To define the membrane compartments in which CLIC1 may reside more precisely, we used immuofluorescence studies of three distinct cell lines: Panc1 cells, a poorly differentiated, non-polarized cell line derived from a human pancreatic cancer; T84 cells, a well-differentiated, highly polarized cell line derived from human colon cancer; and MPTC cells, an immortalized kidney proximal tubule cell line derived from a mouse transgenic for temperature-sensitive SV40 large T antigen.