IGF1 and progeroid syndrome: Furthermore, XpdTTD mice, which manifest accelerated ageing in many (but not all) organs and tissues, have recently been shown to display features related to a caloric restricted–like phenotype and suppression of the GH/IGF1 axis in a limited set of organs and tissues, stressing the segmental nature that is characteristic of all progeroid syndromes and the systemic nature of the response [64].