IGF1 and Hypoglycemia: In mammals, IGF1-deficient, Ames and Snell dwarf mice (characterized by defects in the development of the anterior pituitary due to mutations in the Prop-1 and Pit1 loci and diminished levels of GH, thyroid stimulating hormone, and prolactin hormone) combine hypoglycemia, low body temperature, and increased storage of carbohydrates and lipids [40,42] with up-regulation of antioxidant defense capacity and extended lifespan [49,50].