POMC and Hypoglycemia: As depicted in Figure 3, control participants responded to hypoglycemia with strong increases in mean concentrations of epinephrine (p = 0.005, for the ANOVA time factor), norepinephrine (p < 0.001), ACTH (p = 0.009), cortisol (p = 0.015), and growth hormone (p = 0.012).