Identification of host genetic factors, including inherited, highly penetrant mutations in cancer susceptibility for hereditary breast cancer (BRCA1, BRCA2), familial polyposis coli (APC), and those predisposing to hereditary non-polyposis colon cancer, among others, in combination with knowledge of environmental factors, have the potential to reduce cancer morbidity and mortality by early detection and prevention [5,6,9,10,89–91]. This evidence concerns the gene APC and hereditary nonpolyposis colon cancer.