XRCC1 and fibrosis: As shown in Table 6, there is a statistically significant excess of XRCC1 R399Q RQ heterozygotes in patients with telangiectasia (P=0.01; G-test), and an excess of TT homozygotes in patients with fibrosis (P=0.003; G-test), suggesting that the risk of telangiectasia and fibrosis as late normal tissue injury phenotypes is determined by multiple independent factors.