SELE and chronic myelogenous leukemia, BCR-ABL1 positive: Earlier it was demonstrated that DOX induced neutrophil adhesion that was mediated via overexpression of E-selectin (Abou El Hassan et al, 2003). Therefore, it is tempting to speculate that CML is derived from these pathways and could play a role in DOX-induced vascular endothelial injury and subsequent cardiotoxicity.