NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive: Activation of RAGE by binding of CML is thought to lead to the nuclear translocation of NF-κB (Sousa et al, 2000) and the activation of several secondary messenger systems that increase the production of proinflammatory cytokines and adhesion molecules (Boulanger et al, 2002).