Furthermore, in gastric cancer significant relationships between TUNEL, Ki67 and grade have been reported (Jesionek-Kupnicka et al, 2002), whereas in oral leukoplakia higher levels of TUNEL, Ki67 and p53 have been reported, indicating increased instability of the genome and higher severity of the dysplasia and the clinical stage (Kovesi and Szende, 2004). This evidence concerns the gene TP53 and gastric cancer.