In this study, by analyzing the effect of the DNA methylation inhibitor hydralazine and the HDAC inhibitor valproate on cervical cancer cell lines and primary tumors of patients with cervical cancer treated with these drugs we demonstrate that although these drugs in vitro may increase oncoprotein gene expression, which correlates with demethylation and histone acetylation, in patients E6 and E7 transcripts are mainly unchanged. Here, HDAC9 is linked to cervical cancer.