Because hydralazine and valproate inhibit the growth of cervical cancer cell lines in studies and did not negatively affect their E6 and E7 expression, we wanted to investigate the changes at p53 that plays an important role in HPV carcinogenesis, on the basis that we had observed up-regulation of this tumor suppressor gene in patients with breast cancer on treatment with these drugs [25]. This evidence concerns the gene TP53 and breast cancer.