In a meta-analysis on thromboembolic prophylaxis in total knee arthroplasty,18 comparison of several agents used in DVT prophylaxis (LMWH, warfarin, aspirin, heparin, mechanical methods, antithrombin III and dextran) with placebo, showed that for total DVT, all agents except dextran and aspirin, provided significantly better protection than did placebo (p < 0.0001). Here, SERPINC1 is linked to deep vein thrombosis.