The following discussion will expand to deal with the following topics: 1) muscle involvement in Graves' disease and TAO, 2) effects of eccentric muscle action on muscle inflammation, 3) calsequestrin and the Ca2+ regulation system, 4) involvement of the connective tissue and superoxide dismutase (SOD), 5) propioception and biomechanical implications, 6) functional imaging data in relation to the model, and 7) summary of the WOMED concept of lateral tension in the context of inflammation and IL-6. The gene discussed is IL6; the disease is thromboangiitis obliterans.