Gene-based (Table 1) and SNP-based (Table S1) analyses showed promising associations (i.e., p-value for trend or likelihood ratio test [LRT]; 2 degrees of freedom [df] <0.01) with bladder cancer risk for 19 genes: VEGF, STK11, CYP1B1, ZNF350, PTH, GHR, CASP9, PLA2G6, GSTA4, ROS1, RB1CC1, TERT, XRCC4, FZD7, CETP, CYP24A1, LIPC, ESR1, and HSD17B4. In addition, ARHGDIB, SHBG, GPX4, and STAT1 showed significant associations with risk according to the LRT (2 df); however, estimates for heterozygous and homozygous variants showed associations in opposite directions (Table S2). Here, ESR1 is linked to urinary bladder cancer.