An exploratory analysis of 1,433 SNPs in or near 386 genes involved in cancer-related pathways using the GoldenGate assay led to the identification of novel associations for several promising genes, the most notable finding, a 5′ UTR SNP in VEGF. Subsequent analyses that captured nearly all common variants in this gene showed additional associations with SNPs in the promoter and intron 2, providing further evidence for the importance of variation in regulatory elements of VEGF and bladder cancer risk. This evidence concerns the gene VEGFA and urinary bladder cancer.