The discovery that NHERF-1 and 2 bind the C-terminal DTHL motif of Podocalyxin's cytosolic tail has led to speculation that formation of NHERF/Podocalyxin complexes may be the key mechanistic step in 1) formation of apical domains in epithelial cells, 2) dissolution of cell-cell junctions between normal epithelial cells or during tumor progression, 3) generation of highly-interdigitated foot processes for normal podocyte function, and 4) blocking hematopoietic cell adhesion [2], [8], [11], [12], [13], [15], [16]. The gene discussed is NHERF1; the disease is neoplasm.