The sustained induction of hEGR1 by EGF in the RT112 bladder tumour cells for 24 and 48 h, in addition to the rapid induction seen at 1 to 2 h, indicates that further investigation of the role of hEGR1 and EGFR in bladder tumours is warranted. The gene discussed is EGF; the disease is urinary bladder neoplasm.