MMP1 and neoplasm: Despite the absence of a direct correlation between the MMP-1 2G polymorphism (associated with high MMP-1 protein expression) and MMP-1 staining in the tumour tissue, this comes as no surprise as MMP-1 tissue expression may be influenced by host immune response, disease stage, therapy, etc. Moreover, the immunohistochemical technique we employed may not be the method of choice to identify such an association, as it represents only a single period in tumour evolution.