The most extensively studied MMP SNP in relation to cancer is the −1607 bp insertion/deletion in the MMP-1 promoter (Rutter et al, 1998; Nishioka et al, 2000; Ghilardi et al, 2001; Zhu et al, 2001; Hinoda et al, 2002; Tower et al, 2002; Wyatt et al, 2002; Zinzindohoue et al, 2005; Elander et al, 2006). This evidence concerns the gene MMP1 and cancer.