Overexpression of MMP-1 (Murray et al, 1996), MMP-2 (Papadopoulou et al, 2001), and MMP-3 (Roeb et al, 2004) has been linked to poor prognosis, high tumour stage, and enhanced tumour invasiveness in patients with CRC. The gene discussed is MMP2; the disease is colorectal carcinoma.