STAT3 and cancer: Other methods that targets the Stat3 signaling pathway in cancer cells have also been explored, which include using anti-sense RNA (Grandis et al, 2000; Epling-Burnette et al, 2001; Calvin et al, 2003; Chiarle et al, 2005), siRNA (Konnikova et al, 2003; Lee et al, 2004), small molecules (Song et al, 2005; Turkson et al, 2005) and decoy-oligos (Leong et al, 2003; Chan et al, 2004).