CCND1 and neoplasm: Furthermore, increased β-catenin may translocate to the nuclei and could serve as a transcriptional factor by binding to the T-cell factor/lymphoid enhancing factor (Tcf-Lef) family [5], leading to transcription of specific genes stimulating tumor formation, such as cyclin-D1, c-myc, c-jun, fra-1, uPAR, ZO-1, MMP7, NBL4, DRCTNNB1A, MCP-3 [6-12].