We are currently exploring whether this training set and our current set of features can be used to evaluate UCVs in other genes associated with familial cancer syndromes: MLH1, MSH2, MSH6 (hereditary nonpolyposis colon cancer), APC (familial adenomatous polyposis), MYH (MYH adenomatous polyposis), and P16 (melanoma). The gene discussed is MSH6; the disease is melanoma.