The collagen-binding RTKs, DDR1 and DDR2, have previously been linked to various human diseases including fibrosis (Alves et al, 1995; Mao et al, 2002; Lee et al, 2004; Avivi-Green et al, 2006), atherosclerosis (Hou et al, 2001; Hou et al, 2002; Ferri et al, 2004), and cancer (Johnson et al, 1993; Alves et al, 1995; Barker et al, 1995; Nemoto et al, 1997; Weiner et al, 2000; Dejmek et al, 2003; Ongusaha et al, 2003; Heinzelmann-Schwarz et al, 2004; Ram et al, 2006; Vogel et al, 2006). This evidence concerns the gene DDR2 and cancer.