Erroneous targeting of cryptic sites located near the LMO2 and TAL2 proto-oncogenes in t(11;14)(p13;q11) and t(7;9)(q34;q32) translocations, respectively, represent prototypical examples of such oncogenic translocations in T-cell acute lymphoblastic leukemia (T-ALL) [8,29,35–37]. The gene discussed is LMO2; the disease is T-cell acute lymphoblastic leukemia.