As upregulated MHC class I expression directly mediates recognition by Ag-specific T-cells in inflammatory conditions [46,47], these results suggest that poly-ICLC treatment may directly sensitize GL261 glioma cells to the CTL-mediated immuno-surveillance via induction of Type-I IFN and the resultant upregulation of MHC class I and IP-10 production. This evidence concerns the gene CXCL10 and central nervous system cancer.