We report that: 1) poly-ICLC can serve as a safe and effective adjuvant to improve the efficacy of Ag-specific peripheral vaccinations in mouse CNS tumor models, including the GL261 glioma; 2) VLA-4 expression on CTLs plays a significant role in the efficient CNS tumor infiltration of Ag-specific CTLs induced by the vaccinations and poly-ICLC treatment; 3) efficient CNS tumor homing of Ag-specific T-cells was also associated with Ag-specific IFN-γ production of BILs, suggesting the improved Type-1 function of tumor infiltrating CD8+ T effector cells as a result of poly-ICLC co-administration. Here, CD8A is linked to central nervous system cancer.