No differences in retinal occludin content were detected between eyes receiving rAAV-lacZ and rAAV-angiostatin injection at 1 (rAAV-lacZ: 45.82±3.08 pixels, rAAV-angiostatin: 43.62±2.78) and 5 days (rAAV-lacZ: 38.96±2.22 pixels, rAAV-angiostatin: 40.65±3.46 pixels) after induction of diabetes. The gene discussed is OCLN; the disease is diabetes mellitus.