MBD4 and cancer: In humans, a naturally occurring frameshift mutation of a polynucleotide tract in MBD4 has been found in microsatellite unstable (MSI) colon and other cancers (Bader et al, 1999; Riccio et al, 1999; Menoyo et al, 2001; Yamada et al, 2002) that leads to a premature stop in translation of the mRNA.