At IHC the median number of Chalkley counts in the MCF7/HER2-18 cell line fell from 12 (IQR 9—14) in the control tumours to 9 (IQR 6–10) in the treated samples (P=0.0001), and from 7 (IQR 5–19) in the MDAMB231 tumours, to 4 (IQR 3–6) in the treated samples (P=0.0001) (Table 2). Here, ERBB2 is linked to neoplasm.