In an additional experiment, we prepared CD4+CD25- CCR2-transfected T cells by transduction of recombinant retrovirus carrying the pMXs-IG-mCCR2 vector into CD4+CD25- T cells and compared pneumonitis and sialadenitis among control, CD4+CD25- T cell-transferred, and CD4+CD25- CCR2-transferred MRL/lpr mice. The gene discussed is CD4; the disease is sialadenitis.