PIK3R1 and PLCG1 are involved in intracellular signaling cascades and their differential regulation is known to be involved in tumorigenesis [28,29], while POU2F1 interacts with several known breast cancer-associated proteins (i.e. BRCA1, BARD1 and PARP1) [30,31]. The gene discussed is BRCA1; the disease is breast carcinoma.