Eight non-validated gene products occupy critical positions in this component, connecting validated and/or benchmark proteins: BCAR1 (breast cancer anti-estrogen resistance 1) links ADAM12 and GSN, therefore mediating extracellular matrix and cytoskeleton remodeling; and three gene products show a high degree of connectivity (between 5–10 interactions; PIK3R1, PLCG1 and POU2F1), which suggests a central role in the transmission of molecular information within this component. The gene discussed is PIK3R1; the disease is breast cancer.