We showed that anti-LC1 and anti-SLA autoantibodies are not detected by conventional assays in the vast majority of patients with chronic viral hepatitis B and C. Based on these results we cannot find any justification for the application of anti-LC1 and anti-SLA tests in the routine laboratory testing of viral hepatitis-related autoantibody serology unless anti-LKM1 antibodies are present in HCV-infected patients. Here, SLA is linked to animal viral hepatitis.