Detection of anti-soluble liver antigen antibodies (anti-SLA) was initially considered to identify a third type of AIH seronegative for the conventional ANA, SMA, anti-LKM1 autoantibodies [15] but recent studies indicate that it can also be present in conjunction with other AIH-specific antibodies suggesting that anti-SLA is rather an additional important marker for the diagnosis of type 1 AIH, than a marker of a third type of AIH [11,16-19]. This evidence concerns the gene BTG3 and autoimmune hepatitis.