TGIF1 and holoprosencephaly: This conception can be illustrated by the finding of a TGIF nonsense mutation in a fetus presenting a semilobar HPE with cebocephaly, turricephaly, microcephaly and flat face detected by ultrasound, but also in her father who presented only mild signs like hypotelorism and lateral cleft lip, although this stop mutation was predicted to encode a truncated version of the TGIF protein missing two repression domains [106].