The pathogenesis of KS is however still unclear and appears complex, involving various mechanisms dependent on both viral and cellular activities related to inflammation and angiogenesis promoted by endothelial growth factors (β-FGF, PDGF, VEGF) including HIV-Tat as well as cell proliferation and anti-apoptosis (vBCL2) [2,13,26,27]. The gene discussed is VEGFA; the disease is Kaposi's sarcoma.