There seems to be a cross talk between HIV-1 and HHV-8 as recent studies have shown that HIV-1 replication stimulates HHV-8 production in PEL cell lines and peripheral blood mononuclear cells from KS patients, possibly due to the activating functions of HIV-Tat [65, 66] ORF50, the major transactivator of HHV-8 lytic cycle can also induce increased levels of HIV replication by interacting synergistically with HIV-1 Tat leading to increased cell susceptibility to HIV infection and transient permissiveness to HIV replication [67]. This evidence concerns the gene TAT and HIV infectious disease.