RUNX1 and leukemia: Two leukemia-associated chromosome translocations, the t(8;21)(q22;q22) and the t(16;21)(q24;q22), result in the fusion between the N-terminal region of AML1 and the C-terminal regions of two almost identical chromatin corepressors, MTG8 and MTG16, leading to the formation of AML1-MTG8 and AML1-MTG16, respectively [10-13].