Even differentiated-type carcinomas of the G-phenotype are more likely to transform into the undifferentiated-type carcinoma and show infiltrative growth to deeper layers of the mucosa or invasion of the surrounding structures through loss of the E-cadherin gene function than tumours of the I-phenotype (Tajima et al, 2001b, 2004; Yamazaki et al, 2006). This evidence concerns the gene CDH1 and neoplasm.