CEACAM1, L1 and HPA-binding carbohydrates (GalNAc/GlucNAc) might have multiple function supporting melanoma metastasis, namely invasion into and migration through the ECM as well as adhesion to the endothelium and transendothelial migration or tumour vascularisation (Ergün et al, 2000; Voura et al, 2001; Gutwein et al, 2003; Ebrahimnejad et al, 2004; Schumacher et al, 2005), which can now be analysed in our model system. Here, CEACAM1 is linked to melanoma.