Neutralizing anti- PCDGF antibody reversed basal as well as LPA, ET-1 and 8-CPT-induced ovarian cancer cell growth and induced apoptosis, indicating that PCDGF is a growth and survival factor for ovarian cancer, induced by LPA and ET-1 and cAMP/EPAC through ERK1/2 [23]. The gene discussed is GRN; the disease is ovarian cancer.