Theseresults hint at a relationship between repression of PPARγactivity in adipocytes via interaction with N-CoR/SMRT andactivation of vitamin D receptor responses in osteoblasts.Unraveling a potential relationship between repression ofPPARγ activity via interaction with N-CoR/SMRT andenhancement of bone formation may provide new therapeutic targetsin treating osteoporosis in the aging population. The gene discussed is NCOR2; the disease is osteoporosis.