The cluster I haplotype Hap3 had an additive protective effect on rate of progression to CD4+ < 200 and AIDS 1993 (RH = 0.71–0.68 per allele, p = 0.026–0.006, respectively), and the cluster I Hap7 had a slight accelerating effect (CD4+ < 200, RH = 1.25, p = 0.056; AIDS-93, RH = 1.31, p = 0.010, respectively) (Table S2). Here, CD4 is linked to AIDS.