However, few studies have investigated annexin expression in bone cells: annexin 1 (Anx-A1), annexin 2, and annexin 5 are expressed in the human osteosarcoma cell line MG-63 [2] and rat primary osteoblasts and, at least Anx-A1, might modulate bone ontogeny as demonstrated for the murine palate [5]. Here, ANXA1 is linked to osteosarcoma.