Treatment of CML has undergone several major advancements: a) The development of chemotherapeutic interventions such as busulphan and 6-thioguanine in 1953; b) The introduction of alpha interferon in 1983; c) Bone marrow transplantation in 1986; and d) BCR-ABL-specific tyrosine kinase inhibitors in 1998 [1]. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.