Therapeutic interventions for CML aim to accomplish three goals: to achieve a hematologic remission (normalization of leukocyte numbers), to achieve cytogenetic remission (0% Ph-positive cells on chromosomal analysis), and, to achieve molecular remission (negative PCR result for the BCR-ABL fusion transcript) [2]. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.