Calorie restriction depressed splenic and lymph node CD8+ cell number (F2,36 = 98.2, p < 0.0001 and F2,36 = 11.7, p = 0.0001, Fig. 3 and 4), with a significant interaction "diet x immunization" in the case of spleen (F2,36 = 11.9, p = 0.0001), i.e., the decrease in CD8+ cell number observed after SCH immunization in control and 33% calorie restricted rats was no longer found in 66% calorie-restricted animals (Fig. 3). Here, CD8A is linked to spindle cell hemangioma.