However, in contrast with previously published data showing a negative correlation between fra-1 expression and hormone receptor status in mammary carcinoma cell lines, no significant differences were observed in the FRA-1 expression among different morphological grading of the breast carcinoma samples and other prognostic indicators of breast carcinomas (ER and PgR receptors, Ki67 and ERB-B2), Therefore, its detection does not seem to have any prognostic value. Here, ESR1 is linked to breast carcinoma.