In a Sardinian study of psoriasis, HLA-C*05 was found to be significantly underrepresented (protective) in patients, although it was not established whether this effect is independent of or secondary to the overrepresentation of HLA-C*06 and/or haplotypes containing risk alleles at the nearby corneodesmosin (CDSN) gene,55 in which our most highly associated SNP, rs3132552, is found. The gene discussed is HLA-C; the disease is psoriasis.