The third example is "BP: G-protein coupled receptor protein signalling pathway" in "CC: integral to plasma membrane", Holland JD et al [25] showed that CXCR4 is subject to controlled regulation in breast cancer cells via differential G protein-receptor complex formation, and this regulation may play a role in the transition from nonmetastatic to malignant tumors. The gene discussed is CXCR4; the disease is breast carcinoma.