Strong nuclear expression of NPM was found in carcinomas originating from stratified epithelia derived from several organs, including the skin, oesophagus, cervix, and lung, in carcinomas from glandular epithelia from the breast, thyroid gland, lung, digestive tract, ovary, and prostate, and in other malignancies such as B-cell lymphoma, renal cell carcinoma, and glioblastoma. Here, NPM1 is linked to renal cell carcinoma.