Also, the convincing mechanistic demonstration was performed mostly with cancer cell lines treated with the demethylating agent 5-aza-2′-deoxycytidine (DAC) and contradicts the fact that DKK1 is secreted by many highly proliferative cancer cell lines (Figures 1B, 3G and 4C) and is detected in many breast, kidney and lung cancer specimens. The gene discussed is DKK1; the disease is lung cancer.