To contribute to the controversial discussion about the influence of HER2/neu overexpression on ovarian cancer prognosis and whether the chemokine receptor system SDF-1/CXCR4 is significantly involved in this process, we examined the expression of these three potential oncoproteins by means of immunohistochemistry on tissue microarrays comprising 148 ovarian cancer patients. The gene discussed is CXCR4; the disease is ovarian carcinoma.