To contribute to the controversial discussion about the influence of HER2/neu overexpression on ovarian cancer prognosis and whether the chemokine receptor system SDF-1/CXCR4 is significantly involved in this process, we examined the expression of these three potential oncoproteins by means of immunohistochemistry on tissue microarrays comprising 148 ovarian cancer patients. This evidence concerns the gene CXCR4 and ovarian cancer.