A highly significant correlation of c-met expression with ETAR and ETBR was found; 92.6% of c-met positive DCIS versus 56.7% of c-met negative DCIS stained positive for ETAR (P < 0.001), and 57.4% of c-met positive tumours versus 23.4% of c-met negative tumours stained positive for ETBR (P < 0.001). The gene discussed is EDNRA; the disease is ductal breast carcinoma in situ.