KLK6 is a trypsin-like enzyme that can degade in vitro laminin and fibronectin (Bernett et al, 2002), as well as other basic constituents of the extracellular matrix (ECM) and the basement membrane (Magklara et al, 2003), and could be linked to tumour cell growth and malignant transformation. The gene discussed is KLK6; the disease is neoplasm.