Most strikingly, 12 kallikreins (KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK10, KLK11, KLK13, KLK14, and KLK15) are concurrently upregulated in ovarian cancer (Borgono and Diamandis, 2004). The gene discussed is KLK4; the disease is ovarian cancer.