Deregulation of c-Met and HGF have been shown to correlate with a poor outcome in several major human tumours, particularly breast carcinomas (Beviglia et al, 1997; Ghoussoub et al, 1998; Camp et al, 1999; Nakipoulou et al, 2000; Tolgay Ocal et al, 2003; Christensen et al, 2005; Lee et al, 2005). This evidence concerns the gene MET and breast carcinoma.