MET and cancer: However, initial attempts using in vivo models of small-molecule therapy, based on inhibition of RTKs by Glivec, Iressa and Tarceva that are used for treatment of multiple human cancers, have revealed a lack of selectivity towards c-Met inhibition (Maulik et al, 2002; Ma et al, 2003; Pennacchietti et al, 2003; Christensen et al, 2005; Gasparini et al, 2005).