Multivariate analysis including FIGO stage, postoperative residual tumour, ECOG performance status, age and Ki-S5 proliferation activity, established an independent prognostic significance of both pRb ISI (odds ratio: 2.98, P=0.002) and p16INK4a expression (odds ratio 2.41, P=0.009 (Table 4). This evidence concerns the gene CDKN2A and neoplasm.