PLAU and cancer: A recently developed selective u-PA inhibitor, WX-UK1 impaired development of lung metastases in a rat model of spontaneous metastatic orthotopic breast adenocarcinoma, whereas Ertongur et al (2004) demonstrated that this compound inhibited in vitro tumour cell Matrigel invasion by a variety of human cancer cell lines (Setyono-Han et al, 2005).