Clearly, the additional benefit of ECSOD was not much greater than the solo effect of catalase that reduced optic disc edema by 32% with a mean optic nerve head area of 30,754 μm2 (Wt OD) relative to 45,354 μm2 for untreated eyes (Wt OS; p<0.01). Here, CAT is linked to optic papillitis.