ISG15 and cancer: Among the cancer-associated genes, the Cancer-Testis Antigen 2 (CTAG-2) is very strongly expressed (30-fold according to the GeneChip data), as are ARHGDIB/Ly-GDI, and IGFBP6. The cytokine induced genes [35] include a set previously reported as increasing in post-selection HMEC, such as IFIT1, IFITM1, G1P2 and OAS1 [36].